“Eight healthy babies were born in Britain,” reports Phys.org, “with the help of an experimental technique that uses DNA from three people to help mothers avoid passing devastating rare diseases to their children, researchers reported Wednesday.”
Mutations in mitochondrial DNA “can cause a range of diseases in children that can lead to muscle weakness, seizures, developmental delays, major organ failure and death,” and in rare cases even pre-IVF testing can’t clearly detect their presence.
Researchers have been developing a technique that tries to avoid the problem by using the healthy mitochondria from a donor egg. They reported in 2023 that the first babies had been born using this method… Using this method means the embryo has DNA from three people — from the mother’s egg, the father’s sperm and the donor’s mitochondria — and it required a 2016 U.K. law change to approve it. It is also allowed in Australia but not in many other countries, including the U.S. Experts at Britain’s Newcastle University and Monash University in Australia reported in the New England Journal of Medicine Wednesday that they performed the new technique in fertilized embryos from 22 patients, which resulted in eight babies that appear to be free of mitochondrial diseases. One woman is still pregnant…
Robin Lovell-Badge [a stem cell and developmental genetics scientist at the Francis Crick Institute who was not involved in the research] said the amount of DNA from the donor is insignificant, noting that any resulting child would have no traits from the woman who donated the healthy mitochondria…
In the U.K., every couple seeking a baby born through donated mitochondria must be approved by the country’s fertility regulator. As of this month, 35 patients have been authorized to undergo the technique. Critics have previously raised concerns, warning that it’s impossible to know the impact these sorts of novel techniques might have on future generations… But in countries where the technique is allowed, advocates say it could provide a promising alternative for some families.
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