Cancer death rates in the U.S. have fallen by approximately one-third since the 1990s when adjusted for age, according to data cited in a new analysis of global cancer trends. The decline represents a steady, year-over-year reduction that began in the early 1990s and continues across developed countries.
Prevention efforts have contributed substantially to the decline. Reduced smoking rates in wealthy nations prevented more than 3 million cancer deaths since 1975 in America alone. Britain’s HPV vaccination program, launched in 2008 for teenage girls, produced a 90% reduction in cervical cancer rates among women in their 20s within 15 years. Treatment advances have transformed outcomes for specific cancers. Childhood leukemia, once virtually fatal, now has a five-year survival rate above 90%.
Researchers have identified inexpensive drugs with cancer-prevention properties, including aspirin, which cuts bowel cancer risk in half for patients with Lynch syndrome. Future progress faces obstacles, however, including high treatment costs and planned cuts to the National Cancer Institute under the Trump administration. China overtook America as the primary source of cancer research in 2025.
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